Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
نویسندگان
چکیده
منابع مشابه
Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro.
BACKGROUND Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several experimental models of fibrosis have provided evidence for the effectiveness of the polypeptide hormone relaxin as a potential antifibrotic agent. This study was conducted to further elucidate the a...
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متن کاملhyperbaric environment up-regulates cd15s expression on leukocytes, down-regulates cd77 expression on renal cells and up-regulates cd34 expression on pulmonary and cardiac cells in rat
objective(s): the aim of this study was to estimate effects of hyperbaric (hb) treatment by determination of cd15s and cd11b leukocyte proinflammatory markers expression. in addition, this study describes changes in cd77 and cd34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. materials and methods:expression of cd11b and cd...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2004
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfg598